LEF-1 expression in human colorectal cancer. 74% of cases displayed no LEF-1 expression, neither in main tumor areas (A) nor in cells of the invasion front (B). Lymphocytes were LEF-1 positive and served as internal positive control. 26% of cases showed LEF-1 expression which could be found either only in main tumour areas (C) which occured in 16 cases or only in cells of the invasive front (D) which was seen in 5 cases or homogenously distributed throughout the tumour which was found in 35 cases. Scale bar 100 μm.