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Table 1 Metabolic parameters

From: Exploring the molecular mechanisms underlying the potentiation of exogenous growth hormone on alcohol-induced fatty liver diseases in mice

 

Control

GH1-treated control

Alcohol

GH1-treated alcohol

Pair-fed I

Pair-fed II

BAC (mmol/l)

-

-

22.13 ± 2.28

16.20 ± 1.54###

-

-

β-OHB (μmol/l)

88.5 ± 10.48d

246.4 ± 41.2a

122.7 ± 15.36c

164.53 ± 19.80b

94.87 ± 10.43d

92.80 ± 11.98d

TG (mmol/l)

1.24 ± 0.31

1.13 ± 0.13

1.54 ± 0.22*

1.16 ± 0.28

1.15 ± 0.25

1.17 ± 0.32

TC (mmol/l)

4.04 ± 0.48

3.95 ± 0.36

3.91 ± 0.47

3.99 ± 0.60

4.10 ± 0.35

4.08 ± 0.28

IGF-1 (ng/ml)

393.95 ± 46.65

415.32 ± 39.97

384.53 ± 38.75

400.55 ± 50.78

399.05 ± 34.67

387.37 ± 21.68

Insulin (μU/ml)

24.90 ± 2.19

25.89 ± 2.45

24.47 ± 1.92

25.60 ± 2.43

24.60 ± 1.88

24.76 ± 2.42

Glucose (mmol/l)

6.46 ± 0.36

6.85 ± 0.45

6.23 ± 0.25

6.79 ± 0.42

6.32 ± 0.43

6.28 ± 0.47

HOMA-IR

7.14 ± 0.56

7.85 ± 0.61* ##

6.78 ± 0.62

7.71 ± 0.38* #

6.92 ± 0.92

6.88 ± 0.47

TNFα (pg/ml)

8.50 ± 2.03#

7.95 ± 1.75##

10.83 ± 2.07*

8.77 ± 1. 94#

8.20 ± 1.77#

8.80 ± 1.93#

Hepatic MDA (μM)

3.39 ± 1.09

2.27 ± 0.67* ##

3.77 ± 1.03

2.87 ± 0.81

3.17 ± 0.92

3.05 ± 0.59

  1. n = 6 mice per group. *P < 0.05 vs. the control group; #P < 0.05, ##P < 0.01 or ###P < 0.001 vs. the alcohol group. HOMA-IR: homeostasis model assessment of insulin resistance; MDA: malondialdehyde; β-OHB: β-hydroxybutyrate; TC: total cholesterol; TG: triglyceride; TNFα: tumor necrosis factor-α.