Table 4 Zinc Transporters (Importers) and Cancer

Erythroleukemia

ZIP1

In the vesicular compartment and partly in the ER in adherent cells

[99]

Squamous cell carcinoma

ZIP2

mRNA is induced by contact inhibition and serum starvation

[202]

Prostate

ZIP1, ZIP2, ZIP3

Down-regulated in malignant cells

[203]

Pancreas

ZIP4

Over-expression is linked to increased cell proliferation

[106]

Breast

ZIP6, ZIP10

Expression is linked to metastasis to lymph node

[204, 205]

Tamoxifen resistant breast cancer

ZIP7

Increased levels results in increased growth and invasion

[182, 206, 207]