|
Condition
|
Healthy % (+ SEM)
|
Ulcerative colitis (UC) % (+ SEM)
|
Adenoma (AD) % (+ SEM)
|
Adenocarcinoma (AC) % (+ SEM)
|
|---|
|
Compartment
|
Endothelium
|
Epithelium
|
Stromal
|
Endothelium
|
Epithelium
|
Stromal
|
Endothelium
|
Epithelium
|
Stromal
|
Endothelium
|
Epithelium
|
Stromal
|
|---|
|
Marker
| | | | | | | | | | | | |
|
CD31
|
6.7 (± 0.5)
|
n.d.
|
n.d.
|
10.5(± 0.5)
|
n.d.
|
n.d.
|
11.2(± 0.9)
|
n.d.
|
n.d.
|
14.6(± 1)
|
n.d.
|
n.d.
|
|
HGF
|
n.d.
|
35.1(± 2.1)
|
n.d.
|
n.d.
|
15.5(± 1.3)
|
n.d.
|
n.d.
|
19.3(± 1.5)
|
n.d.
|
n.d.
|
17.3(± 1.5)
|
n.d.
|
|
CD68
|
n.d.
|
n.d.
|
8.7(± 1.0)
|
n.d.
|
n.d.
|
18(± 0.8)
|
n.d.
|
n.d.
|
23(± 2.3)
|
n.d.
|
n.d.
|
26.6 (± 1.8)
|
|
CD15
|
1.4(± 0.3)
|
1 (± 0.4)
|
2.5(± 0.6)
|
2.6(± 0.2)
|
4.7(± 0.7)
|
7.0(± 1.3)
|
3.3(± 0.4)
|
11.6(± 2.4)
|
16.(± 1.9)
|
3.6(± 0.6)
|
13.4(± 1.0)
|
22.8(± 2.5)
|
|
TLR-4
|
2.4(± 0.3)
|
3.6(± 0.9)
|
5.8(± 1.5)
|
4.0(± 0.4)
|
8.2(± 1.6)
|
16.1(± 1.5)
|
6.6(± 0.5)
|
16.8(± 2.5)
|
25.4(± 2.8)
|
8.0(± 0.8)
|
19.6(± 3.3)
|
28.2(± 2.7)
|
|
IL-6
|
2.9(± 0.2)
|
4.9(± 0.5)
|
7.06(± 0.2)
|
4.1 (± 0.3)
|
11.2(± 1.2)
|
17.2(± 1.4)
|
6(± 0.4)
|
21.5(± 2.0)
|
27.9(± 3.2)
|
6.8(± 0.8)
|
32.0(± 3.0)
|
34.6(± 2.7)
|
- Shown are the averaged percentages of cells (± Standard Error of the Mean-SEM) positive for staining within each tissue compartment. UC = ulcerative colitis; AD = adenomas; AC = adenocarcinomas; n.d. = not detected.
