Disease Free Survival (DFS) curves of adenocarcinoma patients associated with TLR-4 expression in the tumor stroma. Disease free survival (time from diagnosis to relapse, progression or death of disease) were estimated for each marker by means of Kaplan Meier method for patients with CRC using the Survival Analysis System Excel addin by SG Shering, Univ College of Dublin. 6a DFS curve of all adenocarcinoma patients (pT1-4) (53 cases). CRC patients with a low percentage of TLR-4+ cells in the tumor stromal compartment (less than the median value corresponding to 20% of the cells positive) relapsed with a greater time interval and several showed survival of over 100 months, while those patients with a percentage of TLR-4+ cells in the stromal compartment higher than the median value relapsed earlier and fewer showed long term survival (RR 2.36; log rank chi-square 4.25, p < 0.05). 6b DFS curve of patients with adenocarcinoma at the pT3 (33 cases) stage. Patients with a percentage of TLR-4+ cells in the tumor stromal compartment more than 50% relapsed early (within 14 months), while those with a percentage of TLR-4+ cells expression less than 50% relapsed much later (within 40 months, RR 3.15; log rank chi-square 4.03, p < 0.05).