IL-6 expression in human colon tissues. 2a Expression of IL-6 in normal healthy tissues (A), ulcerative colitis (B), adenomas (C) and adenocarcinomas (D); some scattered epithelial and stromal cells are stained with weak intensity. In the dysplastic conditions there is an increased staining (magnification ×400). 2b Different expression of IL-6 in endothelial, epithelial and stromal compartments show that in all groups this marker is significantly increased respect to healthy tissues (mean ± SEM; **P < 0.01, *** P < 0.001). HT = healthy tissues (N = 16); UC = ulcerative colitis (N = 13), AD = adenomas (N = 34; 29 low and 5 high grade), AC = adenocarcinomas (N = 53; 7 T1, 10 T2, 33 T3, 3 T4).