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Table 3 Phenotypic characterization of T-cell subpopulations

From: Quantification of newly produced B and T lymphocytes in untreated chronic lymphocytic leukemia patients

   Patients Controls  
   median IQR* median IQR  
Th cells % 10.2 4.7-23.9 50.9 43.5-54.7 P = 0.002
  cells/μL 1 585 1 275-2 533 1 029 785-1 428 P = 0.05
naive Th cells % 46.4 27.2-49.5 51.1 46.5-62.5 NS
  cells/μL 715 381-834 533 363-786 NS
thymicnaive Th cells % 54.4 41.9-63.6 64.1 58.4-70.1 NS
  cells/μL 345 228-447 333 223-545 NS
Treg % 4.8 3.3-6.1 5.4 4.7-7.4 NS
  cells/μL 82 44-123 62 44-80 NS
thymicnaive-Treg % 2.0 1.5-3.0 1.8 1.0-2.9 NS
  cells/μL 8 4-17 7 4-11 NS
TEM % 22.4 10.9-31.9 10.4 8.0-11.5 P = 0.04
  cells/μL 245 202-367 98 80-146 P = 0.0002
TCM % 30.8 24.1-40.1 30.7 26.7-37.8 NS
  cells/μL 520 270-957 308 248-401 NS
CTL % 4.1 3.0-9.0 24.8 22.2-29.0 P < 0.0001
  cells/μL 479 350-780 483 387-539 NS
  1. T-cell subpopulations were determined by six-color flow cytometric analysis using various combinations of monoclonal antibodies. The percentage of Th cells and CTL is obtained after gating on lymphocytes, that of naive Th cells, Treg, TEM and TCM after gating on Th cells, and that of thymicnaive Th cells after gating on naive Th cells. The percentage of thymicnaive Treg is obtained after gating on thymicnaive Th cells. *Abbreviations: IQR, Interquartile range; Th cells, T helper cells; Treg, regulatory T cells; TEM, effector memory T cells; TCM, central memory T cells; CTL, cytotoxic T cells.