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Table 3 Phenotypic characterization of T-cell subpopulations

From: Quantification of newly produced B and T lymphocytes in untreated chronic lymphocytic leukemia patients

  

Patients

Controls

 
  

median

IQR*

median

IQR

 

Th cells

%

10.2

4.7-23.9

50.9

43.5-54.7

P = 0.002

 

cells/μL

1 585

1 275-2 533

1 029

785-1 428

P = 0.05

naive Th cells

%

46.4

27.2-49.5

51.1

46.5-62.5

NS

 

cells/μL

715

381-834

533

363-786

NS

thymicnaive Th cells

%

54.4

41.9-63.6

64.1

58.4-70.1

NS

 

cells/μL

345

228-447

333

223-545

NS

Treg

%

4.8

3.3-6.1

5.4

4.7-7.4

NS

 

cells/μL

82

44-123

62

44-80

NS

thymicnaive-Treg

%

2.0

1.5-3.0

1.8

1.0-2.9

NS

 

cells/μL

8

4-17

7

4-11

NS

TEM

%

22.4

10.9-31.9

10.4

8.0-11.5

P = 0.04

 

cells/μL

245

202-367

98

80-146

P = 0.0002

TCM

%

30.8

24.1-40.1

30.7

26.7-37.8

NS

 

cells/μL

520

270-957

308

248-401

NS

CTL

%

4.1

3.0-9.0

24.8

22.2-29.0

P < 0.0001

 

cells/μL

479

350-780

483

387-539

NS

  1. T-cell subpopulations were determined by six-color flow cytometric analysis using various combinations of monoclonal antibodies. The percentage of Th cells and CTL is obtained after gating on lymphocytes, that of naive Th cells, Treg, TEM and TCM after gating on Th cells, and that of thymicnaive Th cells after gating on naive Th cells. The percentage of thymicnaive Treg is obtained after gating on thymicnaive Th cells. *Abbreviations: IQR, Interquartile range; Th cells, T helper cells; Treg, regulatory T cells; TEM, effector memory T cells; TCM, central memory T cells; CTL, cytotoxic T cells.
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Journal of Translational Medicine

ISSN: 1479-5876

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