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Table 2 Number of KRECs and TRECs and average number of B-cell divisions

From: Quantification of newly produced B and T lymphocytes in untreated chronic lymphocytic leukemia patients

   Patients Controls  
   median IQR* median IQR  
KRECs /106 PBMC 200 99-448 5 372 2 798-7 617 P = 0.0001
  /mL 3 763 1 318-6 486 12 942 6 556-19 490 P = 0.0001
Average number 6.7 3.8-14.1 4.0 3.0-4.5 P = 0.003
of B-cell divisions      
TRECs /106 PBMC 216 64-949 1 374 834-3 046 P = 0.002
  /mL 2 869 1 601-11 812 3 053 1 960-6 401 NS
  1. KRECs and TRECs were determined by Real-Time PCR. Results are given both as copies/106 PBMC and copies/mL. The average number of B-cell divisions was calculated as the difference between the cycle threshold number obtained by PCR amplification of signal joints, and the cycle threshold number obtained after amplification of coding joints.
  2. *Abbreviations: IQR, Interquartile range; KRECs, kappa-deleting recombination excision circles; TRECs, T-cell receptor excision circles.