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Table 2 Number of KRECs and TRECs and average number of B-cell divisions

From: Quantification of newly produced B and T lymphocytes in untreated chronic lymphocytic leukemia patients

  

Patients

Controls

 
  

median

IQR*

median

IQR

 

KRECs

/106 PBMC

200

99-448

5 372

2 798-7 617

P = 0.0001

 

/mL

3 763

1 318-6 486

12 942

6 556-19 490

P = 0.0001

Average number

6.7

3.8-14.1

4.0

3.0-4.5

P = 0.003

of B-cell divisions

     

TRECs

/106 PBMC

216

64-949

1 374

834-3 046

P = 0.002

 

/mL

2 869

1 601-11 812

3 053

1 960-6 401

NS

  1. KRECs and TRECs were determined by Real-Time PCR. Results are given both as copies/106 PBMC and copies/mL. The average number of B-cell divisions was calculated as the difference between the cycle threshold number obtained by PCR amplification of signal joints, and the cycle threshold number obtained after amplification of coding joints.
  2. *Abbreviations: IQR, Interquartile range; KRECs, kappa-deleting recombination excision circles; TRECs, T-cell receptor excision circles.
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Journal of Translational Medicine

ISSN: 1479-5876

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