Quantification of newly produced B and T lymphocytes in untreated chronic lymphocytic leukemia patients

Table 1 Demographic, clinical and laboratory parameters of CLL patients

Patients	1	2	3	4	5	6	7	8	9	10	11	12	Controls (range)
Age	68	65	69	68	48	77	73	53	67	53	56	66	50-69
Gender	M*	M	M	M	M	M	M	F	M	M	M	F	na
Rai stage	0	0	0	0	0	0	0	0	0	0	0	0	na
Binet stage	A	A	A	A	A	A	A	A	A	A	A	A	na
Lymphocytes/μL	12 350	30 210	27 500	8 050	5 290	38 470	47 810	14 330	6 030	10 980	24 680	11 360	950-4 612
Haemoglobin (g/dL)	15.6	13.4	14.0	14.2	14.4	13.5	11.7	15.5	16.0	15.2	14.5	14.2	14-18
Platelets (10³/μL)	236	216	173	128	247	211	139	160	150	147	220	183	130-400
β2-microglobulin (mg/L)	2.0	2.5	2.8	2.2	1.9	2.1	4.7	2.0	3.7	2.4	2.5	2.4	< 2.5
Direct Antiglobulin Test	neg	neg	neg	neg	neg	neg	neg	neg	neg	neg	neg	neg	neg
IgVH mutational status	mut	unm	mut	unm	mut	unm	mut	unm	mut	unm	mut	mut	na
FISH	del13q14	neg	del13q14	neg	neg	del13q14	del13q14	del13q14	neg	neg	neg	del13q14	na
IgG (mg/dL)	979	1 104	936	857	740	908	672	551	702	904	860	1 448	690-1 500
Clonally expanded chains	Igλ	Igκ	Igκ	Igλ	Igλ	Igλ	Igκ	Igκ	Igκ	Igκ	Igκ	Igκ	na
IgA (mg/dL)	190	368	107	186	113	86	234	40	123	211	243	106	85-410
IgM (mg/dL)	38	58	38	53	113	15	36	36	17	46	13	95	40-240

*Abbreviations: M, male; F, female; na, not applicable; neg, negative; IgVH, immunoglobulin heavy chain variable genes; mut, mutated; unm, unmutated; FISH, fluorescence in situ hybridization.

ISSN: 1479-5876