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Table 3 The analyses of factors regarding OS and disease-free survival

From: Co-evolution of cancer microenvironment reveals distinctive patterns of gastric cancer invasion: laboratory evidence and clinical significance

Variables OS DFS
N Median (Range) P * N Median (Range) P *
Clinico-pathological data       
Pathological types       
   Adenocarcinoma 25 19.0 (1.5-52.5) 0.860 20 14.0 (1.0-52.5) 0.796
   Nonadenocarcinoma 12 22.0 (3.0-53.0)   9 25.0 (2.0-53.0)  
   Serosa invasion       
No (T1/T2) 8 44.0 (2.0-52.5) 0.024 7 45.0 (13.0-52.5) 0.038
Yes (T3/T4) 29 13.0 (1.5-53.0)   22 9.3 (1.0-53.0)  
   Lymph node metastasis       
No 10 22.0 (1.5-53.0) 0.213 9 38.0 (6.0-52.5) 0.681
Yes 27 12.5 (2.0-33.0)   20 11.3 (1.0-53.0)  
Distant metastasis       
M0 29 22.0 (1.5-53.0) 0.021    
M1 8 12.5 (2.0-33.0)     
   TNM stage       
Early 11 44.0 (11.0-52.5) 0.009 11 46.0 (42.0-52.5) 0.006
Advanced 26 12.0 (1.5-53.0)    18 26.5 (8.0-51.5)
Immunohistochemistry (IHC)       
   MMP9       
Positive 30 13.5 (1.5-52.0) 0.036 23 9.5 (1.0-51.5) 0.171
Negative 7 44.0 (13.0-53.0)   6 43.5 (25.0-53.0)  
   MMP2       
Positive 20 14.0 (1.5-53.0) 0.867 13 9.0 (1.0-53.0) 0.395
Negative 17 22.0 (7.0-51.5)   16 20.0 (4.0-51.5)  
   Type IV collagen       
Positive 30 25.5 (1.5-53.0) 0.044 25 19.0 (1.0-53.0) 0.646
Negative 7 10.0 (2.0-42.0)   4 9.3 (2.0-42.0)  
   Macrophages       
Low density 16 40.5 (1.5-53.0) 0.056 16 37.0 (1.0-53.0) 0.013
High density 21 13.0 (2.0-53.0)   21 9.5 (2.0-49.0)  
   MVD       
Low 19 39.0 (11.0-53.0) 0.001 16 21 (3.0-53) 0.209
High 18 8.5 (1.5-53.0)   13 6.0 (0.5-49.0)  
  1. * Log-rank test (Two-tailed), bold font representing significant data (P < 0.05).