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Table 1 Clinical studies of agents targeting inflammatory pathways in acute ischemic stroke.

From: Inflammatory mechanisms in ischemic stroke: therapeutic approaches

Neuroprotective Agent Mode of Action Reference
Recombinant human IL-1RA Interleukin-1 receptor antagonist [67]
Enlimomab Anti-ICAM-1 monoclonal antibody [68]
Tirilazad Lipid peroxidation inhibitor [69]
UK-279, 276 Neutrophil inhibitory factor [70]
Cerovive (NXY-059) Nitrone-based free radical trapping agent [71, 72]
Acetaminophen (Paracetamol) Anti-pyretic effect [73]
Minocycline Anti-inflammatory [74]
Ginsenoside Ca2+ channel antagonist [75]
Edaravone MCI-186 Free radical scavenger [76]
ONO-2506 (Arundic Acid) Astrocyte modulator [77]
  1. Adapted from Shah et al., 2009 [78].