Table 1 Clinical studies of agents targeting inflammatory pathways in acute ischemic stroke.
From: Inflammatory mechanisms in ischemic stroke: therapeutic approaches
Neuroprotective Agent | Mode of Action | Reference |
|---|---|---|
Recombinant human IL-1RA | Interleukin-1 receptor antagonist | [67] |
Enlimomab | Anti-ICAM-1 monoclonal antibody | [68] |
Tirilazad | Lipid peroxidation inhibitor | [69] |
UK-279, 276 | Neutrophil inhibitory factor | [70] |
Cerovive (NXY-059) | Nitrone-based free radical trapping agent | |
Acetaminophen (Paracetamol) | Anti-pyretic effect | [73] |
Minocycline | Anti-inflammatory | [74] |
Ginsenoside | Ca2+ channel antagonist | [75] |
Edaravone MCI-186 | Free radical scavenger | [76] |
ONO-2506 (Arundic Acid) | Astrocyte modulator | [77] |