Figure 4

CpG enhances CP-870,893-mediated T cell stimulatory capacity of B cells. Purified CD19+ B cells were stimulated as in Figure 2 and used as stimulators in an MLR as described in Figure 3. (A) Percentage of CFSE^low T cells and (B) T cell IFN-gamma production (left panel) or T cell IL-2 production (right panel) are shown for responding T cells at a B cell to T cell ratio of 1:2. Mean values for 7 donors tested are shown with standard deviations. * indicates p < 0.05 for the comparisons shown, ** indicates p < 0.01. neg, negative control; CP, CP-870,893 incubation; CpG, CpG ODN 2006 incubation.