Figure 2

CD19+ B cell cytokine secretion in response to in vitro stimulation. Purified CD19+ B cells were stimulated with the negative control hIgG2 antibody and control ODN (neg), CD40 agonist mAb CP-870,893 (CP), CpG ODN 2006 (CpG), or both CP-870,893 and CpG ODN 2006 (CP + CpG). (A) IL-6 and (B) IL-10 concentrations were measured using cytokine bead array of supernatant at 48 hr. Mean values for 7 donors tested are shown with standard deviations. ** indicates p < 0.01 for the comparisons shown.