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Table 1 Association of the UCHL1 mRNA and protein expression pattern with the methylation status

From: Epigenetic control of the ubiquitin carboxyl terminal hydrolase 1 in renal cell carcinoma

 

UCHL1 expression

Methylation pattern

RCC cell line

mRNA

protein

BstU I

Taq I

sequencing

MZ1257RC

+

+

U

U

U

MZ1774RC

+

+

U

U

U

MZ1790RC

(+)

-

M

M

P

MZ1851RC

+

+

U

U

U

MZ1851LN*

(+)

-

M

M

M

MZ1879RC

-

-

M

M

M

MZ1940RC

-

-

M

M

M

MZ1973RC

+

+

U

U

U

MZ2175RC

-

-

P

P

P

MZ2733RC

+

+

U

U

U

MZ2789RC

+

-

P

P

P

MZ2858RC

+

+

U

U

U

MZ2861RC

+

+

U

U

U

MZ2862RC

(+)

-

P

M

P

MZ2885RC

+

n.d.

U

U

U

MZ2904RC

+

+ (pp)

P

P

P

MZ2905RC

+

+

U

U

U

  1. *Cell line derived from a lymph node metastasis of a patient suffering from RCC. The methylation pattern of the UCHL1 promoter DNA was determined by COBRA and/or sequencing.
  2. (-): no expression detectable; ((+)) weak expression detectable; (+) expression detectable; (U) unmethylated UCHL1 promoter; (P): partially methylated UCHL1 promoter (M): fully methylated UCHL1 promoter; (pp): expression verified by proteomic profiling of the corresponding RCC lesion; n.d. not done
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Journal of Translational Medicine

ISSN: 1479-5876

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