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Table 1 TRIP-Br2 expression profiling in human tissues by interrogation of the Novartis GNF SymAtlas v1.2.4 microarray database

From: TRIP-Br2 promotes oncogenesis in nude mice and is frequently overexpressed in multiple human tumors

Human tissues

TRIP-Br2 gene expression

Bronchial epithelial cells

++

Lung

+

Whole brain

+

Bone marrow*

+++

Thymus*

++++

Lymph node

++

Tonsil*

+++

Heart

+

Liver

+

Kidney

+

Skin

+

Pancreas

+

Skeletal muscle

+

Cardiac myocytes

+

Smooth muscle*

+++

Placenta*

+++

Prostate

++

Uterus

++

Ovary

+

Testis

+

Lymphohematopoietic cell lineages

 

BM-CD34+ cells*

++++

BM-CD71+ early erythroid cells*

++++

BM-CD105+ endothelial cells*

+++

BM-CD33+ myeloid cells*

++++

PB-CD56+ NK cells*

++++

PB-BDCA4+ dendritic cells*

+++

PB-CD14+ monocytes*

++++

PB-CD19+ B cells*

++++

B lymphoblasts*

++++

CD4+ T cells*

+++

CD8+ T cells*

+++

  1. The median (med) was calculated based on expression of TRIP-Br2 across all human tissues; med × 3: 3-fold more than the median; med × 10: 10-fold more than the median. In silico TRIP-Br2 expression, (χ), across all human tissues was scored via the following scheme: +: (χ) ≤ median; ++: median < (χ) ≤ med × 3, +++: med × 3 <(χ) ≤ med × 10, ++++: med × 10 <(χ). TRIP-Br2 is found to be highly expressed in human tissues such as bone marrow, thymus, tonsil and smooth muscle. TRIP-Br2 is also highly expressed in the highly proliferative lymphohematopoietic cell lineages. *Denotes high TRIP-Br2 expression in these cells and tissues. BM: Bone marrow-derived; PB: Peripheral blood-derived.