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Figure 4 | Journal of Translational Medicine

Figure 4

From: TRIP-Br2 promotes oncogenesis in nude mice and is frequently overexpressed in multiple human tumors

Figure 4

TRIP-Br2 expression is dysregulated in many human cancer cell lines. (A) Western blot analyses revealed overexpression of TRIP-Br2 in the human cancer cell lines U2OS, PC3, 769-P, HCT-116, HepG2 and MCF-7. Data was obtained from three independent experiments that were performed in triplicates. (B) Immunocytochemical analyses showed that TRIP-Br2 is found predominantly in both the nuclei of WI38 and U2OS cells. Cellular DNA was counterstained with DAPI (blue). (C) Subcellular fractionation analyses revealed that TRIP-Br2 is overexpressed and preferentially localized to the nuclei of U2OS, PC3, 769-P, HCT-116 and HepG2 cells. Data was obtained from three independent experiments that were performed in triplicates.

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