Figure 3
Steady-state blood concentrations of successively higher generation Gd-dendrimers over time in rodents. Gd-G1 dendrimers (MW 6 kDa), Gd-G2 dendrimers (MW 11 kDa), Gd-G3 dendrimers (MW 19 kDa), lowly conjugated (LC) Gd-G4 dendrimers (MW 25 kDa), and standard Gd-G4 dendrimers (MW 40 kDa) maintain peak blood concentrations for only a few minutes. Gd-G5 dendrimers (MW 80 kDa) maintain peak blood concentrations for over 2 hours. Gd-G6 dendrimers (MW 130 kDa), Gd-G7 dendrimers (MW 330 kDa), and Gd-G8 dendrimers (MW 597 kDa) also maintain peak blood concentrations for over 2 hours similar to those of Gd-G5 dendrimers (concentration profiles not shown for purposes of figure clarity). Respective Gd-dendrimer generations administered intravenously over 1 minute at a Gd dose of 0.09 mmol Gd/kg animal body weight. Blood concentrations of Gd-dendrimers over time measured in the superior sagittal sinus. Gd-G1 (n = 4), Gd-G2 (n = 6), Gd-G3 (n = 6), lowly conjugated (LC) Gd-G4 (n = 4), Gd-G4 (n = 6), Gd-G5 (n = 6), Gd-G6 (n = 5), Gd-G7 (n = 5), and Gd-G8 (n = 6). Error bars represent standard deviations. Adapted from reference[73].