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Table 2 Extrinsic factors with prognostic relevance

From: Intrinsic and extrinsic factors influencing the clinical course of B-cell chronic lymphocytic leukemia: prognostic markers with pathogenetic relevance

Factors Negative prognosis if expressing Cases with unfavourable values, mean % (range) Putative mechanisms responsible for unfavourable prognosis
BCR - UM IGHV
- stereotyped BCR?
- M IGHV3-23?
42.3 (40–46)a - high reactivity or polyreactivity
- superantigens recognition?
ZAP-70 >20% 44.7 (36–52)b - tyrosine phosphorylation
- calcium influx
- chemokine sensitivity
CD38 >30% 36.3 (30–44)c - microenviromental interactions (CD38/CD31)
CD49d >30% 36.5 (28–43)d - microenviromental interactions (CD49d/VCAM-1; CD49d/Fibronectin)
  1. aDeduced from [25, 91, 92];
  2. bDeduced from [7, 114, 116];
  3. cDeduced from [25, 127, 128];
  4. dDeduced from [8, 150, 152].