Table 2 Extrinsic factors with prognostic relevance
Factors | Negative prognosis if expressing | Cases with unfavourable values, mean % (range) | Putative mechanisms responsible for unfavourable prognosis |
|---|---|---|---|
BCR | - UM IGHV - stereotyped BCR? - M IGHV3-23? | 42.3 (40–46)a | - high reactivity or polyreactivity - superantigens recognition? |
ZAP-70 | >20% | 44.7 (36–52)b | - tyrosine phosphorylation - calcium influx - chemokine sensitivity |
CD38 | >30% | 36.3 (30–44)c | - microenviromental interactions (CD38/CD31) |
CD49d | >30% | 36.5 (28–43)d | - microenviromental interactions (CD49d/VCAM-1; CD49d/Fibronectin) |