Figure 7

Protein Tyrosine Kinase and other Major Kinases involved in Angiogenic Pathways. Pathways were constructed by the direct Interaction Function Bioinformatics Programs of Stratagene Pathway Architect. ALL proteins mapped in this figure have been either upregulated or expressed de novo post-HIV-infection. Proteins were uploaded and function-specific pathways were generated automatically for protein tyrosine kinases expressed in HIV-infected cells. Note that the newly discovered angiogenic pathways involve distinct protein tyrosine kinases and signaling proteins as described in the text. These pathways are independent of VEGFR2-VEGFC interactions as they do not interact with any of the proteins expressed in HIV-infected cells. Full names of all protein abbreviations and accession numbers are listed in Table 1.