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Figure 5 | Journal of Translational Medicine

Figure 5

From: Proteomic characterization of HIV-modulated membrane receptors, kinases and signaling proteins involved in novel angiogenic pathways

Figure 5

T-Cell Activation Pathways Generated by HIV-Modulated Proteins. Graphic representation of major proteins and kinases involved in T-cell activation; the pathways were constructed by the direct Interaction Function Bioinformatics Programs of Stratagene Pathway Architect 2.0.1. All proteins were uploaded and function-specific pathways were generated automatically; blue outlines around red ovals (ZAP 70, CRKL, and TNR9), indicate the activated proteins. Note numerous cell surface proteins including PI3K involved in T-cell activation pathways. Lines between red ovals denote major interactions; green circles represent small molecule interactions. Full names of all protein abbreviations and accession numbers are listed in Table 1.

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