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Table 2 ROC analysis of EBV serological parameters for NPC diagnosis

From: Clinical values of multiple Epstein-Barr virus (EBV) serological biomarkers detected by xMAP technology

EBV biomarker AUC (95% CI) Cutoff (FI) Sensitivity (95% CI) Specificity (95% CI)
IgA – EA-D 0.87 (0.85–0.89) 500 80% (77–83%) 77% (73–80%)
IgA – gp125 0.78 (0.75–0.80) 700 69% (65–73%) 73% (69–77%)
IgA – EBNA1 0.81 (0.79–0.84) 300 70% (66–74%) 76% (72–80%)
IgA – gp78 0.76 (0.73–0.79) 300 66% (62–70%) 72% (68–76%)
IgA – p18 0.72 (0.69–0.75) 500 60% (56–64%) 74% (70–78%)
IgG – EA-D 0.90 (0.88–0.92) 1000 81% (77–84%) 84% (81–87%)
IgG – EBNA1 0.68 (0.65–0.71) 1400 67% (63–71%) 61% (57–65%)
IgG – gp78 0.74 (0.71–0.76) 1600 62% (58–66%) 71% (67–74%)
  1. NOTE. ROC analysis is made by using the data from the Cantonese panel, including sera from healthy subjects (n = 542) and NPC patients (n = 547) detected by xMAP technology. AUC, area under ROC curve; FI, fluorescence intensity; CI, confidence interval; EA-D, early antigen-diffused; EBNA1, Epstein-Barr nuclear antigen 1.