Table 2 ROC analysis of EBV serological parameters for NPC diagnosis
EBV biomarker | AUC (95% CI) | Cutoff (FI) | Sensitivity (95% CI) | Specificity (95% CI) |
|---|---|---|---|---|
IgA – EA-D | 0.87 (0.85–0.89) | 500 | 80% (77–83%) | 77% (73–80%) |
IgA – gp125 | 0.78 (0.75–0.80) | 700 | 69% (65–73%) | 73% (69–77%) |
IgA – EBNA1 | 0.81 (0.79–0.84) | 300 | 70% (66–74%) | 76% (72–80%) |
IgA – gp78 | 0.76 (0.73–0.79) | 300 | 66% (62–70%) | 72% (68–76%) |
IgA – p18 | 0.72 (0.69–0.75) | 500 | 60% (56–64%) | 74% (70–78%) |
IgG – EA-D | 0.90 (0.88–0.92) | 1000 | 81% (77–84%) | 84% (81–87%) |
IgG – EBNA1 | 0.68 (0.65–0.71) | 1400 | 67% (63–71%) | 61% (57–65%) |
IgG – gp78 | 0.74 (0.71–0.76) | 1600 | 62% (58–66%) | 71% (67–74%) |