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Table 3 Analysis of immunological parameters in peripheral blood.

From: Phase I/II open-label study of the biologic effects of the interleukin-2 immunocytokine EMD 273063 (hu14.18-IL2) in patients with metastatic malignant melanoma

Evaluation

Any Difference

(Mack Skillings Test)

Paired Comparisons*

(Signed Rank Test)

 

Raw P Value

Adjusted P Value

P Value of Cycle 1 Comparisons

P Value of Cycle 2 Comparisons

CD4+

0.0203

0.1827

-

-

CD8+

0.0207

0.1827

-

-

CD56+

-

-

0.1250

-

CD16+/CD56+

-

-

1.0

-

CD25+

0.3192

1.0

-

-

CD27+

0.0709

0.4254

-

-

NK+ granzyme B+

0.2623

1.0

-

-

CD8+ granzyme B+

0.0948

0.4740

-

-

NK activity

0.0207

0.1827

-

-

ADCC w/IL2

0.2818

1.0

-

-

ADCC

0.5095

1.0

-

-

S100

-

-

0.3621

-

IL6

0.0366

0.0732

-

-

sIL2R

<0.0001

<0.0001

0.0156

0.0156

TNF

0.1948

0.1948

-

-

IL10

0.0115

0.0345

0.0769

0.250

Neopterin

<0.0001

<0.0003

0.0156

0.0222

  1. * For data with 3 or more serial observations, a Mack-Skillings test adjusted p < 0.05 was required to conduct paired comparisons. For selected parameters with too few observations, a paired (signed rank) test was conducted.