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Table 3 Analysis of immunological parameters in peripheral blood.

From: Phase I/II open-label study of the biologic effects of the interleukin-2 immunocytokine EMD 273063 (hu14.18-IL2) in patients with metastatic malignant melanoma

Evaluation Any Difference (Mack Skillings Test) Paired Comparisons* (Signed Rank Test)
  Raw P Value Adjusted P Value P Value of Cycle 1 Comparisons P Value of Cycle 2 Comparisons
CD4+ 0.0203 0.1827 - -
CD8+ 0.0207 0.1827 - -
CD56+ - - 0.1250 -
CD16+/CD56+ - - 1.0 -
CD25+ 0.3192 1.0 - -
CD27+ 0.0709 0.4254 - -
NK+ granzyme B+ 0.2623 1.0 - -
CD8+ granzyme B+ 0.0948 0.4740 - -
NK activity 0.0207 0.1827 - -
ADCC w/IL2 0.2818 1.0 - -
ADCC 0.5095 1.0 - -
S100 - - 0.3621 -
IL6 0.0366 0.0732 - -
sIL2R <0.0001 <0.0001 0.0156 0.0156
TNF 0.1948 0.1948 - -
IL10 0.0115 0.0345 0.0769 0.250
Neopterin <0.0001 <0.0003 0.0156 0.0222
  1. * For data with 3 or more serial observations, a Mack-Skillings test adjusted p < 0.05 was required to conduct paired comparisons. For selected parameters with too few observations, a paired (signed rank) test was conducted.