Treatment group | Total | ||||||
---|---|---|---|---|---|---|---|
IMPDH1 | Week | Belatacept (n = 4) | Cyclosporine (n = 3) | ||||
E0 | 0 | 0.63 | (0.54–0.76) | 0.44 | (0.37–0.79) | 0.59 | (0.37–0.79) |
1 | 0.56 | (0.32–1.1) | 0.75 | (0.67–0.75) | 0.67 | (0.32–1.1) | |
2 | 0.45 | (0.17–0.54) | 0.54 | (0.43–0.62) | 0.50 | (0.17–0.62) | |
13 | 0.42 | (0.25–0.59) | 0.31 | (0.30–0.43) | 0.36 | (0.25–0.59) | |
AUC0–9 h (% of E0 × h) | 1 | 1018 | (866–1128) | 794 | (736–881) | 880 | (736–1128) |
2 | 1146 | (781–1278) | 784 | (741–1146) | 1145 | (741–1622) | |
13 | 1070 | (911–1201) | 1291 | (1193–1540) | 1197 | (911–1540) | |
Emin (% of E0) | 1 | 85.3 | (75.3–115) | 69.3 | (46.8–92.2) | 82.0 | (46.8–115) |
2 | 94.4 | (80.2–103) | 71.1 | (60.7–94.3) | 87.3 | (60.7–103) | |
13 | 97.0 | (57.2–99.6) | 113 | (89.5–117) | 98.3 | (57.2–117) | |
Emax (% of E0) | 1 | 140 | (108–143) | 105 | (102–122) | 121 | (102–143) |
2 | 147 | (105–189) | 107 | (104–151) | 127 | (104–189) | |
13 | 161 | (133–196) | 203 | (173–222) | 185 | (133–222) |