Figure 2
From: KSP inhibitor ARRY-520 as a substitute for Paclitaxel in Type I ovarian cancer cells
ARRY-520 induces apoptosis in Type II EOC cells. Type II EOC cells were treated with 3 μM ARRY-520 for 6, 12, and 24 hours. "0" designation represents non-treated controls. (a) Activity of capase-3, -8, and -9 was measured using Caspase-Glo assay, and (b) effect on XIAP, Caspase-2, and Bid was determined using Western blot analysis. Results shown are for CP70. Similar results were observed with other cells tested.