Figure 6
From: Hypoglycemic and beta cell protective effects of andrographolide analogue for diabetes treatment
AL-1 effectively quenched ROS production induced by high glucose and glibenclamide. RIN-m cells were pretreated with Andro, LA or AL-1 (1 μM) following stimulation with high glucose (275 and 450 mg/dl) or glibenclamide (0.1 and 1 μM) for 2 h. Then the ROS production was measured. Results were calculated by % of AUCCL at 100 mg/ml glucose and 0 μM glibenclamide. (A) ROS production induced by high glucose. *P < 0.05 vs. 450 mg/dl glucose treatment alone; (B) ROS production induced by glibenclamide (Gli). **P < 0.05 vs. 1 μM glibenclamide treatment alone, n = 8 replicates per group.