Skip to main content
Figure 3 | Journal of Translational Medicine

Figure 3

From: Hypoglycemic and beta cell protective effects of andrographolide analogue for diabetes treatment

Figure 3

Pathologic and immunohistochemical analysis of mouse pancreas. Alloxan-induced diabetic mice were treated with Andro, AL-1 or glibenclamide for 6 days, the the pancreas were isolated for hematoxylin and eosin staining or anti-insulin immuohistaining. A, Representative morphology of pancreatic islets. a-f: hematoxylin and eosin staining. Arrow showed the islets' position, scale bar: 50 μm; g-l: immunostaining against insulin as visualized by the HRP-DAB method, scale bar: 50 μm. a, g, no-diabetic control; b, h, diabetic + vehicle control; c, i, diabetic + AL-1 20 mg treatment; d, j, diabetic +AL-1 80 mg treatment; e, k, diabetic + Andro 50 mg treatment; f, l, diabetic + glibenclamide 1.2 mg treatemnt. B, Statistic analysis of average area of per islets among different groups (n = 6). *P < 0.01 vs. normal group, **P < 0.01 vs. diabetic group.

Back to article page