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Table 3 Comparison of serum proteome patterns among different sub-groups of breast cancer patients.

From: Mass spectrometry-based serum proteome pattern analysis in molecular diagnostics of early stage breast cancer

Component
m/z value
S.D. p-value Frequency [%]
Age (median = 56.5 years) >median (n = 42) vs. <median (n = 42)
5353.64 11.54 0.020 48.4
2475.96 2.37 0.029 19.9
4098.35 25.90 0.032 22.5
3024.45 11.71 0.035 20.2
4070.43 5.58 0.048 19.2
T – primary tumor size T1 (n = 44)vs. T2 (n = 40)
5353.64 11.54 0.033 21.9
2873.93 7.13 0.038 20.5
5343.98 6.26 0.051 15.8
3024.45 11.71 0.073 32.8
3249.64 5.24 0.075 12.4
N – nodal status N0 (n = 63)vs. N1 (n = 20)
8618.25 10.83 0.024 45.1
8602.25 29.35 0.036 29.5
2909.04 10.58 0.038 32.5
8607.98 5.60 0.040 25.7
8682.92 8.83 0.047 28.2
G – histopathological grade G1+G2 (n = 54)vs. G3 (n = 20)
2937.50 6.76 0.004 34.1
2556.63 8.07 0.007 44.1
2909.04 10.58 0.011 36.8
7547.58 12.44 0.022 37.7
4793.63 5.91 0.026 8.1
ER – estrogen receptor status ER(-) (n = 29) vs. ER(+) (n = 51)
7915.93 29.15 0.038 42.4
6302.67 4.03 0.039 23.6
8246.58 14.13 0.043 27.5
2599.96 3.93 0.044 28.9
3367.65 13.43 0.061 22.4
PR – progesterone receptor status ER(-) (n = 32) vs. ER(+) (n = 49)
7101.57 8.39 0.002 50.7
9965.62 16.77 0.014 37.3
7750.49 24.72 0.015 30.6
3367.65 13.43 0.018 30.5
9934.38 23.21 0.020 28.3
  1. The five spectral components with the lowest p-values were selected for each comparison. Shown are spectral components (m/z values), S.Ds. of the corresponding model Gaussians, and their relative frequencies in classifiers. The p-values (uncorrected) are for differences measured by the Mann-Whitney U test for each individual component.