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Table 1 Characteristics of spectral components that differentiated samples from breast cancer patients and healthy controls.

From: Mass spectrometry-based serum proteome pattern analysis in molecular diagnostics of early stage breast cancer

Component

m/z value

-95% CI

+ 95% CI

S.D.

p-value

Corrected

p-value

Frequency

Change

2294.67

2283.38

2305.96

5.76

1.28e-12

3.84e-10

46%

D

2303,48

2296,88

2310,09

3,37

6.25e-14

1.88e-11

78%

D

2554.37

2540.32

2568.41

7.16

4.13e-07

1.24e-04

1%

U

2845.58

2838.34

2852.81

3.69

3.59e-12

1.08e-09

21%

D

2865.54

2864.46

2866.62

7.73

4.19e-20

1.26e-17

100%

D

3283.73

3265.34

3302.13

9.39

6.60e-07

1.98e-04

1%

U

3360.19

3352.06

3368.31

4.15

5.69e-11

1.71e-08

22%

D

3427.46

3401.71

3453.21

13.14

8.11e-11

2.43e-08

7%

D

3578.73

3577.42

3580.04

9.36

5.84e-18

1.75e-15

99%

D

3874.18

3863.89

3884.47

5.25

8.08e-09

2.42e-06

3%

D

3895.05

3882.03

3908.06

6.64

1.58e-11

4.74e-09

6%

D

4965.77

4945.35

4986.19

10.42

1.91e-08

5.73e-06

5%

D

6061.80

6050.15

6073.45

5.94

9.53e-09

2.86e-06

5%

D

6743.99

6734.13

6753.85

5.03

2.99e-08

8.97e-06

2%

D

  1. Shown are the most frequent spectral components (m/z values), their 95% confidence intervals, standard deviations of the corresponding model Gaussians, and relative frequencies in cancer classifiers built of 4 features. The p-values are for differences between patients and healthy controls measured by the Mann-Whitney U test for each individual component (also shown after the Bonferroni correction against multiple testing). The change refers to either increased (U) or decreased (D) abundance of a given peptide in cancer samples compared to control samples. The three most frequent components are underlined.