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Table 1 Characteristics of spectral components that differentiated samples from breast cancer patients and healthy controls.

From: Mass spectrometry-based serum proteome pattern analysis in molecular diagnostics of early stage breast cancer

Component
m/z value
-95% CI + 95% CI S.D. p-value Corrected
p-value
Frequency Change
2294.67 2283.38 2305.96 5.76 1.28e-12 3.84e-10 46% D
2303,48 2296,88 2310,09 3,37 6.25e-14 1.88e-11 78% D
2554.37 2540.32 2568.41 7.16 4.13e-07 1.24e-04 1% U
2845.58 2838.34 2852.81 3.69 3.59e-12 1.08e-09 21% D
2865.54 2864.46 2866.62 7.73 4.19e-20 1.26e-17 100% D
3283.73 3265.34 3302.13 9.39 6.60e-07 1.98e-04 1% U
3360.19 3352.06 3368.31 4.15 5.69e-11 1.71e-08 22% D
3427.46 3401.71 3453.21 13.14 8.11e-11 2.43e-08 7% D
3578.73 3577.42 3580.04 9.36 5.84e-18 1.75e-15 99% D
3874.18 3863.89 3884.47 5.25 8.08e-09 2.42e-06 3% D
3895.05 3882.03 3908.06 6.64 1.58e-11 4.74e-09 6% D
4965.77 4945.35 4986.19 10.42 1.91e-08 5.73e-06 5% D
6061.80 6050.15 6073.45 5.94 9.53e-09 2.86e-06 5% D
6743.99 6734.13 6753.85 5.03 2.99e-08 8.97e-06 2% D
  1. Shown are the most frequent spectral components (m/z values), their 95% confidence intervals, standard deviations of the corresponding model Gaussians, and relative frequencies in cancer classifiers built of 4 features. The p-values are for differences between patients and healthy controls measured by the Mann-Whitney U test for each individual component (also shown after the Bonferroni correction against multiple testing). The change refers to either increased (U) or decreased (D) abundance of a given peptide in cancer samples compared to control samples. The three most frequent components are underlined.