Skip to main content

Table 1 Physical properties of PAMAM and Gd-PAMAM dendrimers

From: Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors

Dendrimer generation (G) Terminal amines (#) Naked PAMAM molecular weight # (kDa) Gd-PAMAM dendrimer molecular weight (kDa) Gd-DTPA conjugation (%) Molar relaxivity&(1/mM*s)
G5 128 29 79† 52 9.81
G6 256 58 138† 45 10.04
G7 512 116 283‡ 43 9.82
G8 1024 233 490‡ 36 10.05
  1. #molecular weight obtained from Dendritech, Inc.
  2. †molecular weight measured by MALDI TOF MS
  3. ‡mean molecular weight measured by ADF STEM and EFTEM
  4. &molar relaxivity of Gd-DTPA measured to be 4.13 1/mM*s