Table 6 Semiquantitative immunohistological analysis of the tumor marker CEA, effector cell infiltration and effector cell function in the primary colon carcinoma before start of the NK cell-based therapy, the anastomotic relapse before start of the NK cell-based therapy and the duodenom metastases after finishing the NK cell-based therapy
From: Anti-tumor activity of patient-derived NK cells after cell-based immunotherapy – a case report
Cell marker | Primary colon tumor (02/03) | Anastomotic relapse (03/05) | Metastases (04/07) |
|---|---|---|---|
CEA | ++++* | ++++ | ++++ |
CD45 (lymphocytes) | ++ | ++ | ++ |
CD3 (T cells) | +++ | +++ | ++ |
CD4 (helper T cells) | ++ | ++ | ++ |
CD8 (cytotoxic T cells) | +/- | +/- | +/- |
CD56 (NK cells) | - | - | + |
CD1a (APCs) | - | - | - |
CD25 (IL-2 receptor) | + | ++ | +++ |
Perforin (apoptosis inducer) | - | - | - |
Granzyme B (apoptosis inducer) | - | - | + |