Figure 1

Study design upper panel) and clinical history of the patient (bottom panel). A 65 year old patient with an adenocarcinoma of the colon stage IIIc pT3, N2, M0, G2 (02/03) came to our attention at the time of an anastomotic relapse in 03/05. After surgical resection of the colon carcinoma relapse in 06/05, a biopsy was provided to our laboratory for phenotypic characterization. Two months later (08/05), the NK cell therapy was started. The patient received 6 sequential leukapheresis/re-infusion cycles of autologous, ex vivo TKD/IL-2-activated PBMNC on a monthly basis. After a 3-month break, the patient received another 3 cell re-infusions. The patient did not show any signs of metastases at the end of the NK cell therapy, as determined by CT scan. The time interval between the beginning of the NK cell therapy and death was 27 months. Survival following recurrence and overall survival after first diagnosis was 32 and 58 months, respectively.