Figure 5

CHK1 inhibitors potentiate gemcitabine response. Treatment of MIA PaCa-2 cells with the CHK1 inhibitors (A) SB 218078 or (B) PD 407824 in combination with varying concentrations of gemcitabine resulted in a shift of the dose response curves suggesting potentiation of the gemcitabine response. Cell number was assessed and data was normalized to vehicle control and plotted. Data is representative of three independent experiments.