Table 4 Genes down-regulated the most in MPD neutrophils compared to those from healthy subjects (p < 0.05, t-tests)

TPMT

thiopurine S-methyltransferase (TPMT)

6.90

2.14 × 10^-4

CDNA FLJ35883 fis, clone TESTI2008929

4.47

0.00636

ZNF75

zinc finger protein 75 (D8C6) (ZNF75), mRNA.

4.29

3.24 × 10^-3

FAM3B

family with sequence similarity 3, member B (FAM3B), transcript variant 2

4.20

2.11 × 10^-3

UBE2D4

ubiquitin-conjugating enzyme E2D 4 (putative) (UBE2D4)

4.10

3.44 × 10^-3

AK2P2

PREDICTED: adenylate kinase 2 pseudogene 2 (AK2P2)

3.63

8.43 × 10^-3

XP_933530.1

PREDICTED: hypothetical protein XP_933530 [Source:RefSeq_peptide_predicted;Acc:XP_933530]

3.61

6.61 × 10^-4

PVRL2

poliovirus receptor-related 2 (herpesvirus entry mediator B) (PVRL2), transcript variant alpha

3.27

0.0418

CDNA FLJ38039 fis, clone CTONG2013934

3.13

9.00 × 10^-7

NFKBIA

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA)

3.11

4.23 × 10^-3

NFKBIA

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA)

3.07

5.02 × 10^-3

GADD45B

growth arrest and DNA-damage-inducible, beta (GADD45B), mRNA.

3.06

0.0158

PER1

period homolog 1 (Drosophila) (PER1), mRNA.

2.92

6.84 × 10^-3

C9orf89

chromosome 9 open reading frame 89 (C9orf89), mRNA.

2.91

3.51 × 10^-4

DYNC1LI1

dynein, cytoplasmic 1, light intermediate chain 1 (DYNC1LI1)

2.89

2.53 × 10^-3

RYBP

RING1 and YY1 binding protein (RYBP)

2.88

7.27 × 10^-3

WRB

tryptophan rich basic protein (WRB)

2.85

2.21 × 10^-3

ELA2

elastase 2, neutrophil (ELA2)

2.82

0.0180

CNTNAP3B

OTTHUMP00000046146|hypothetical protein LOC389722|novel protein similar to contactin associated protein-like 3 (CNTNAP3)

2.82

6.20 × 10^-6

UBE2E2

ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast) (UBE2E2)

2.80

8.14 × 10^-4

ARL10

ADP-ribosylation factor-like 10 (ARL10)

2.79

6.80 × 10^-3

RPS28

ribosomal protein S28 (RPS28)

2.76

1.28 × 10^-4

C15orf29

chromosome 15 open reading frame 29 (C15orf29)

2.76

9.34 × 10^-3

C20orf199

chromosome 20 open reading frame 199 (C20orf199)

2.71

2.28 × 10^-5

GADD45B

Growth arrest and DNA-damage-inducible, beta

2.69

5.09 × 10^-3

NFKBIE

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon (NFKBIE)

2.66

0.0271

SCARB1

scavenger receptor class B, member 1 (SCARB1), transcript variant 1

2.63

0.0485

TSP50

testes-specific protease 50 (TSP50)

2.62

8.76 × 10^-3

EFR3B

PREDICTED: EFR3 homolog B (S. cerevisiae) (EFR3B)

2.60

0.021

MLSTD1

male sterility domain containing 1 (MLSTD1)

2.59

0.0134