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Table 4 Genes down-regulated the most in MPD neutrophils compared to those from healthy subjects (p < 0.05, t-tests)

From: Gene and microRNA analysis of neutrophils from patients with polycythemia vera and essential thrombocytosis: down-regulation of micro RNA-1 and -133a

Gene   Fold Increase p
TPMT thiopurine S-methyltransferase (TPMT) 6.90 2.14 × 10-4
  CDNA FLJ35883 fis, clone TESTI2008929 4.47 0.00636
ZNF75 zinc finger protein 75 (D8C6) (ZNF75), mRNA. 4.29 3.24 × 10-3
FAM3B family with sequence similarity 3, member B (FAM3B), transcript variant 2 4.20 2.11 × 10-3
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) (UBE2D4) 4.10 3.44 × 10-3
AK2P2 PREDICTED: adenylate kinase 2 pseudogene 2 (AK2P2) 3.63 8.43 × 10-3
XP_933530.1 PREDICTED: hypothetical protein XP_933530 [Source:RefSeq_peptide_predicted;Acc:XP_933530] 3.61 6.61 × 10-4
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) (PVRL2), transcript variant alpha 3.27 0.0418
  CDNA FLJ38039 fis, clone CTONG2013934 3.13 9.00 × 10-7
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA) 3.11 4.23 × 10-3
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA) 3.07 5.02 × 10-3
GADD45B growth arrest and DNA-damage-inducible, beta (GADD45B), mRNA. 3.06 0.0158
PER1 period homolog 1 (Drosophila) (PER1), mRNA. 2.92 6.84 × 10-3
C9orf89 chromosome 9 open reading frame 89 (C9orf89), mRNA. 2.91 3.51 × 10-4
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 (DYNC1LI1) 2.89 2.53 × 10-3
RYBP RING1 and YY1 binding protein (RYBP) 2.88 7.27 × 10-3
WRB tryptophan rich basic protein (WRB) 2.85 2.21 × 10-3
ELA2 elastase 2, neutrophil (ELA2) 2.82 0.0180
CNTNAP3B OTTHUMP00000046146|hypothetical protein LOC389722|novel protein similar to contactin associated protein-like 3 (CNTNAP3) 2.82 6.20 × 10-6
UBE2E2 ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast) (UBE2E2) 2.80 8.14 × 10-4
ARL10 ADP-ribosylation factor-like 10 (ARL10) 2.79 6.80 × 10-3
RPS28 ribosomal protein S28 (RPS28) 2.76 1.28 × 10-4
C15orf29 chromosome 15 open reading frame 29 (C15orf29) 2.76 9.34 × 10-3
C20orf199 chromosome 20 open reading frame 199 (C20orf199) 2.71 2.28 × 10-5
GADD45B Growth arrest and DNA-damage-inducible, beta 2.69 5.09 × 10-3
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon (NFKBIE) 2.66 0.0271
SCARB1 scavenger receptor class B, member 1 (SCARB1), transcript variant 1 2.63 0.0485
TSP50 testes-specific protease 50 (TSP50) 2.62 8.76 × 10-3
EFR3B PREDICTED: EFR3 homolog B (S. cerevisiae) (EFR3B) 2.60 0.021
MLSTD1 male sterility domain containing 1 (MLSTD1) 2.59 0.0134