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Figure 3 | Journal of Translational Medicine

Figure 3

From: Gene and microRNA analysis of neutrophils from patients with polycythemia vera and essential thrombocytosis: down-regulation of micro RNA-1 and -133a

Figure 3

Panel A. Pathway analysis of differentially expressed MPD genes. Ingenuity pathway analysis showing canonical pathways significantly modulated by the genes whose expression differed among the MPD neutrophils compared to healthy subject neutrophils(p < 0.05). A total of 1,270 genes were differentially expressed: 473 were up-regulated and 800 were down-regulated. Only the 30 pathways with the most significant changes are shown. The p value for each pathway is indicated by the bar and is expressed as -1 times the log of the p value. The line represents the ratio of the number of genes in a given pathway that meet the cutoff criteria divided by the total number of genes that make up that pathway. Panel B. Pathway analysis of differentially expressed G-CSF genes. Ingenuity pathway analysis showing canonical pathways significantly modulated by the genes whose expression differed among the G-CSF-mobilized neutrophils compared to healthy subject neutrophils (p < 0.05). A total of 909 genes were differentially expressed: 452 were up-regulated and 457 were down-regulated. Only the 30 pathways with the most significant changes are shown. The p value for each pathway is indicated by the bar and is expressed as -1 times the log of the p value. The line represents the ratio of the number of genes in a given pathway that meet the cutoff criteria divided by the total number of genes that make up that pathway.

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