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Table 3 Relationship between serum CEA or HMGB1 level and pathological characteristics in gastric cancer groups including EGC, AGC, and metastatic GC

From: Serum high mobility group box-1 (HMGB1) is closely associated with the clinical and pathologic features of gastric cancer

Variables (γs) CEA P-value HMGB1 P-value
Depth of invasion (T stage) 0.118 p > 0.05 0.273 p = 0.011
   Lymph node metastases (N stage) 0.131 p > 0.05 0.225 p = 0.039
   Pathological differentiation* -0.040 p > 0.05 0.009 p > 0.05
Lymphovascular or perineural invasion 0.105 p > 0.05 0.067, p > 0.05
   Tumor location 0.037 p > 0.05 0.041 p > 0.05
   Size of tumor 0.147 p > 0.05 0.457 P = 0.017
   Stage§ 0.098 p > 0.05 0.221 p = 0.040
  1. *Gastric cancers are divided into intestinal and diffuse type carcinoma according to Lauren classification of differentiation.
  2. Gastric cancers are divided into three groups according to tumor location; antrum/body, cardia, diffuse.
  3. Gastric cancers are divided into three groups by size; < 3 cm, 3–5 cm and > 5 cm.
  4. §The stage of tumor was defined according to the UICC-TNM classification. Subjects with stage IV were excluded from this analysis.
  5. The relationship between each pathological variable and serum CEA or HMGB1 level in gastric cancer groups including EGC, AGC, and metastatic GC was evaluated by Spearman correlation (for non-continuous variables). γs, Spearman correlation coefficients.