Groups of diseases (n) | Normal (50) | High-risk Group (50)* | EGC Group (40) | AGC Group (45) | Metastatic GC group (42) |
---|---|---|---|---|---|
Clinical factors | |||||
Age (mean ± S.D; year) | 56.0 ± 13 | 57.5 ± 12.3 | 61.5 ± 12.0 | 59.8 ± 13.7 | 54.7 ± 11.9 |
Male/female (n) | 32:18 | 31:19 | 25:15 | 28:17 | 26:16 |
H. pylori infection (-/+, n) | 21:29 | 30:20 | 18:22 | 27:18 | 20:22 |
Pathological factors | |||||
Size of main tumor (cm) | NS | NS | 4.1 ± 2.7 | 9.2 ± 5.9 | 11.8 ± 4.6 |
Differentiation | NS | NS | |||
Intestinal type | 25 | 21 | 14 | ||
Diffuse type | 15 | 24 | 28 | ||
Tumor location | NS | NS | |||
Antrum/Body | 31 | 28 | 21 | ||
Cardia | 9 | 10 | 12 | ||
Diffuse | 0 | 7 | 7 | ||
Depth of invasion | NS | NS | |||
m, sm | 24, 16 | 2, 0 | 0, 0 | ||
mp, ss | 0 | 9, 13 | 3, 10 | ||
se, a1–3 | 0 | 19, 2 | 1, 0 | ||
Lymph-node metastasis | NS | NS | |||
N0 | 39 | 9 | 1 | ||
N1 | 1 | 17 | 2 | ||
N2 | 0 | 10 | 3 | ||
N3 | 0 | 9 | 8 | ||
Lymphovascular invasion (-/+) | NS | NS | 33: 7 | 10: 35 | 6: 10 |
Distant metastatic organ | NS | NS | NS | NS | |
Liver | 18 | ||||
Peritoneum | 19 | ||||
Others† | 16 | ||||
Stage | NS | NS | |||
I | 40 | ||||
II | 19 | ||||
III | 26 | ||||
IV | 42 | ||||
Serum CEA (ng/ml)‡ | 1.7 ± 0.8 | 2.6 ± 1.8 | 1.6 ± 0.9 | 3.8 ± 8.1 | 46.3 ± 551.5 |
Serum HMGB1 (ng/ml)§ | 3.9 ± 3.4 | 6.3 ± 6.3 | 9.9 ± 11.5 | 16.5 ± 27.4 | 14.1 ± 13.2 |