Table 1 Differential expression of genes involved in T-cell anergy and immune tolerance.

BTLA

Induced during activation of T cells;

Expressed on Th1 cells;

Interacts with B7 homolog B7H4.

CD40

Co-stimulatory molecule expressed by B cells, dendritic cells, and follicular dendritic cells.

CD40L

Expressed by activated T cells;

Binds to CD40 on APC.

CD70

Expressed by activated T and B cells;

Induces proliferation of co-stimulated T cells;

Enhances the generation of CTLs.

FASLG

Interacts with FAS and triggers apoptosis.

GZMB

Granzyme B is crucial for apoptosis of target

Cells by CTLs.

HDAC9

Histone deacetylase 9, transcriptional repressor.

ICOS

Inducible T-cell co-stimulator.

IFNG

Th1- and dendritic cell-specific cytokine.

LTA

Lymphotoxin α or tumor necrosis factor β.

PRF1

Perforin, key CTL effector molecule.

TBX21

Th1-specific transcription factor that controls the

expression of IFN-γ.

TNFRSF4

Receptor involved in CD4+ T cell response.

TNFSF10

TNF-like cytokine;

Induces apoptosis of tumor cells.

TNFSF8

TNF-like cytokine;

Induces apoptosis of some lymphoma cells.

CCR4

Receptor for CC chemokines.

GATA3

Transcription factor that favors expression of

Th2-type cytokines.

IL5

Cytokine for growth and differentiation of B cells

and eosinophils.

IL6

Inhibits T cell activation;

Inhibits the CD40L system;

Induces a Th2-type cytokine response.

LAT

Required for TCR-mediated signaling;

Possibly associated with overstimulation and

apoptosis of T cells.

PDCD1

Induction and maintenance of T-cell tolerance.

RNF128

Involved in induction of anergic phenotype

TNFRSF8

Positive regulator of apoptosis;

Limits proliferation of CD+ effector T cells.