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Table 1 Differential expression of genes involved in T-cell anergy and immune tolerance.

From: Semi-allogeneic vaccines and tumor-induced immune tolerance

GENE FUNCTION Fold UP-Regulation
BTLA Induced during activation of T cells;
Expressed on Th1 cells;
Interacts with B7 homolog B7H4.
3.0; 2.7
CD40 Co-stimulatory molecule expressed by B cells, dendritic cells, and follicular dendritic cells. 2.6; 2.7
CD40L Expressed by activated T cells;
Binds to CD40 on APC.
1.6, 2.1
CD70 Expressed by activated T and B cells;
Induces proliferation of co-stimulated T cells;
Enhances the generation of CTLs.
3.0, 1.7
FASLG Interacts with FAS and triggers apoptosis. 2.1, 2.2
GZMB Granzyme B is crucial for apoptosis of target
Cells by CTLs.
3.2, 2.4
HDAC9 Histone deacetylase 9, transcriptional repressor. 3.4, 2.7
ICOS Inducible T-cell co-stimulator. 2.2, 1.7
IFNG Th1- and dendritic cell-specific cytokine. 5.5
LTA Lymphotoxin α or tumor necrosis factor β. 2.1, 1.7
PRF1 Perforin, key CTL effector molecule. 2.4, 2.6
TBX21 Th1-specific transcription factor that controls the
expression of IFN-γ.
TNFRSF4 Receptor involved in CD4+ T cell response. 2.0, 2.1
TNFSF10 TNF-like cytokine;
Induces apoptosis of tumor cells.
2.1, 1.6
TNFSF8 TNF-like cytokine;
Induces apoptosis of some lymphoma cells.
2.1, 1.7
CCR4 Receptor for CC chemokines. (2.9, 2.0)
GATA3 Transcription factor that favors expression of
Th2-type cytokines.
(2.4, 1.5)
IL5 Cytokine for growth and differentiation of B cells
and eosinophils.
(1.3, 4.1)
IL6 Inhibits T cell activation;
Inhibits the CD40L system;
Induces a Th2-type cytokine response.
(5.9, 6.7)
LAT Required for TCR-mediated signaling;
Possibly associated with overstimulation and
apoptosis of T cells.
(2.8, 2.1)
PDCD1 Induction and maintenance of T-cell tolerance. (2.7, 2.0)
RNF128 Involved in induction of anergic phenotype (5.4, 4.5)
TNFRSF8 Positive regulator of apoptosis;
Limits proliferation of CD+ effector T cells.
(4.7, 2.8)
  1. Expression was measured by real-time RT-PCR. Total RNA was purified from splenocytes of vaccinated immune mice and compared to RNA from control, non-immune mice.