Induced during activation of T cells;|
Expressed on Th1 cells;
Interacts with B7 homolog B7H4.
|CD40||Co-stimulatory molecule expressed by B cells, dendritic cells, and follicular dendritic cells.||2.6; 2.7|
Expressed by activated T cells;|
Binds to CD40 on APC.
Expressed by activated T and B cells;|
Induces proliferation of co-stimulated T cells;
Enhances the generation of CTLs.
|FASLG||Interacts with FAS and triggers apoptosis.||2.1, 2.2|
Granzyme B is crucial for apoptosis of target|
Cells by CTLs.
|HDAC9||Histone deacetylase 9, transcriptional repressor.||3.4, 2.7|
|ICOS||Inducible T-cell co-stimulator.||2.2, 1.7|
|IFNG||Th1- and dendritic cell-specific cytokine.||5.5|
|LTA||Lymphotoxin α or tumor necrosis factor β.||2.1, 1.7|
|PRF1||Perforin, key CTL effector molecule.||2.4, 2.6|
Th1-specific transcription factor that controls the|
expression of IFN-γ.
|TNFRSF4||Receptor involved in CD4+ T cell response.||2.0, 2.1|
Induces apoptosis of tumor cells.
Induces apoptosis of some lymphoma cells.
|CCR4||Receptor for CC chemokines.||(2.9, 2.0)|
Transcription factor that favors expression of|
Cytokine for growth and differentiation of B cells|
Inhibits T cell activation;|
Inhibits the CD40L system;
Induces a Th2-type cytokine response.
Required for TCR-mediated signaling;|
Possibly associated with overstimulation and
apoptosis of T cells.
|PDCD1||Induction and maintenance of T-cell tolerance.||(2.7, 2.0)|
|RNF128||Involved in induction of anergic phenotype||(5.4, 4.5)|
Positive regulator of apoptosis;|
Limits proliferation of CD+ effector T cells.