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Table 1 Scoring methods based on p16INK4a expression patterns and subcellular loci in ECA and EMA

From: Scoring mechanisms of p16INK4a immunohistochemistry based on either independent nucleic stain or mixed cytoplasmic with nucleic expression can significantly signal to distinguish between endocervical and endometrial adenocarcinomas in a tissue microarray study

Scoring Method Score categories ECA EMA p-value
C Score 0–3 9 (64.3%) 20 (83.3%) .245a
  Score 4–12 5 (35.7%) 4 (16.7%)  
  Median (Range) 2 (0–12) 2 (0–12) .152
N Score 0–3 3 (21.4%) 17 (70.8%) .006a
  Score 4–12 11 (78.6%) 7 (29.2%)  
  Median (Range) 5 (2–12) 2 (0–9) <0.001b
Mean of C plus N Score 0–3 4 (28.6%) 21 (87.5%) <0.001a
  Score 4–12 10 (71.4%) 3 (12.5%)  
  Median (Range) 4.25 (2–12) 2 (0–10.5) <0.001b
  1. PS:
  2. 1. C: Method of scoring based on independent cytoplasmic staining alone, irrespective of nucleic staining.
  3. 2. N: Method of scoring based on independent nucleic staining alone, irrespective cytoplasmic staining.
  4. 3. Mean of C plus N: Method of scoring based on mean of cytoplasmic score plus nucleic score.
  5. Note:
  6. • The "a" is Chi-squared test with continuity correction or Fisher exact test, the "b" is Mann-Whitney U test using exact significant.
  7. •Using score 4 points as a cutoff, the immunostains are defined "negative" for scores from 0 to 3, and "positive" for scores from 4 to 12 points.