Figure 1From: Scoring mechanisms of p16INK4a immunohistochemistry based on either independent nucleic stain or mixed cytoplasmic with nucleic expression can significantly signal to distinguish between endocervical and endometrial adenocarcinomas in a tissue microarray studyImmunohistochemical analysis of p16INK4a staining in endocervical adenocarcinomas. (a) Photomicrograph revealed adenocarcinoma of endocervix, endocervical type, H&E stain. (b) Photomicrograph revealed tumor with more predominant p16INK4a staining at nuclei than that at cytoplasms. Focally moderately positive nucleic staining and no cytoplasmic staining were identified. (c) Photomicrograph revealed tumor with more predominant p16INK4a staining at cytoplasms than that at nuclei. Diffusely moderately positive cytoplasmic staining and focally weakly nucleic staining were identified. (d) Photomicrograph revealed tumor with dual prdominat p16INK4a staining at both cytoplasms and nuclei. Diffusely strongly positive nucleic staining and cytoplasmic staining were identified. All photomicrographs a, b, c, d were taken in median-powered, ×200Back to article page