Figure 4

The pro-apoptotic activity of the sigma-2 ligand, SV119, is enhanced by conventional chemotherapy in vivo. C57BL/6 mice bearing implanted tumor allografts were treated with a single dose of SV119 and conventional chemotherapy (gemcitabine or paclitaxel). Twenty-four hours after treatment, tumors were harvested and single cell suspensions were generated. Percent active caspase-3 was then measured in tumor cells by flow cytometry. Each experimental group represents an n = 3. Results are expressed as the mean, with bars representing standard error of the mean.