Figure 2

The apoptotic effect of the sigma-2 ligand, SV119, is enhanced by conventional chemotherapy in vitro. Model pancreatic adenocarcinoma cell lines were treated with escalating doses of SV119, SV119 and gemcitabine, or SV119 and paclitaxel. After 24 hours of treatment, percent caspase-3 positive cells were determined by flow cytometry. Results are expressed as the mean, with bars representing standard error of the mean. Experiments were performed in triplicate with comparable results. Where indicated, * = P < 0.01 for SV119+gemcitabine or SV119+paclitaxel vs. SV119-only control.