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Table 2 Estimated Characteristics of Three Testing Methodologies for Norovirus, Based On Latent Class Analysis and Composite Reference Standard.

From: Of gastro and the gold standard: evaluation and policy implications of norovirus test performance for outbreak detection

  Sensitivity (95% CI) Specificity (95% CI) Positive Predictive Value (95% CI) Negative Predictive Value (95% CI)
Latent Class Model, prevalence (95% CI) = 0.42 (0.35, 0.49)
RT 2 -PCR 100% (100%, 100%) 86% (76%, 95%) 88% (74%, 93%) 100% (100%, 100%)
EIA 86% (75%, 95%) 93% (85%, 99%) 92% (80, 98%) 87% (83%, 96%)
EM 18% (8%, 30%) 100% (100%, 100%) 100% (100%, 100%) 63% (55%, 70%)
Composite Reference Standard, prevalence (95% CI) = 0.37 (0.26, 0.49)
RT 2 -PCR 100% (100%, 100%) 78% (66%, 88%) 82% (57%, 86%) 100% (100%, 100%)
EIA 97% (91%, 100%) 96% (90%, 100%) 96% (83%, 100%) 97% (94%, 100%)
EM 20% (9%, 33%) 100% (100%, 100%) 100% (100%, 100%) 68% (56%, 79%)
  1. RT2-PCR, real-time reverse-transcriptase polymerase chain reaction; EIA, enzyme immunoassay; EM, electron microscopy; 95% CI, 95% credible interval based on 100,000 bootstrap iterations.