Table 3 Apoptosis induction in HepG2 cell variants by 48 h treatment with DMSO or 20–300 μM RES

HepG2

1.53 ± 1.6

6.83 ± 1.9

10.93 ± 1.5

31.2 ± 2.1

63.2 ± 0.8

80.6 ± 1.9

CAV1

3.62 ± 1.8

13.2 ± 1.0

17.91 ± 2.5*

78.7 ± 1.7*

93.6 ± 2.0*

97.1 ± 1.7*

CAVM1

2.19 ± 1.8

9.62 ± 1.1

13.5 ± 1.8

23.1 ± 0.9

74.1 ± 1.8*

90.3 ± 0.6*

CAVM2

3.08 ± 1.3

11.5 ± 1.4

15.3 ± 1.6

50.1 ± 1.7*

83.4 ± 1.5*

93.5 ± 2.4*

CAVRNAi

1.37 ± 1.7

5.05 ± 1.4

9.78 ± 1.1

24.8 ± 2.5

57.7 ± 2.4

75.4 ± 3.1

GFP

1.44 ± 1.1

6.05 ± 1.8

11.2 ± 2.0

32.7 ± 1.6

65.4 ± 2.1

82.3 ± 3.0