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Figure 7 | Journal of Translational Medicine

Figure 7

From: Generation in vivo of peptide-specific cytotoxic T cells and presence of regulatory T cells during vaccination with hTERT (class I and II) peptide-pulsed DCs

Figure 7

A, B, C and D. Post-vaccination tetramer analysis with DCT pulsed with class I ± class II hTERT. tetramer+ CD8+T cell responses (mean +/- SD) to DCTs pulsed with class I hTERT epitope alone compared with or without class II epitopes from patients L001–L004; E and F. Responses were higher and statistically significant (p < 0.05) in patients L001, L002, L003 and L004; Responses were higher with class II epitopes but not significant (NS) statistically in patients L005 and L006 (p = 0.089 and p = 0.109) when analysed using the independent t-test. Each histogram represents either baseline (V0) tetramer response or mean (SD) tetramer responses assessed over multiple time points as indicated in the parethesis (V1-Vx; Vx being the last vaccination time point). CD8+T cell tetramer+ response to an irrelevant HLA*A201 MAGE antigen, not used in the vaccination, was measured as a negative control; 150,000 events were acquired and analysed.

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