Regression of orthotopic neuroblastoma in mice by targeting the endothelial and tumor cell compartments

Table 4 Quantification of tumor angiogenesis by stereology

	vessel density (mm^-2)	Lv (mm^-2)	Vv (10^-3)	Sv (mm^-1)
control (n = 9)	39.9 ± 18.5	77.2 ± 37.1	5.1 ± 2.5	2.6 ± 1.3
CHS 828^a (n = 13)	12.8 ± 10.3	25.6 ± 20.5	2.8 ± 2.1	1.0 ± 0.7
Change ^b (%)	-67.1% **	-67.1% **	-44.7%	-62.7% *

CHS 828 was administered at 20 mg/kg/day by oral gavage.
Lv, length of vessels per tumor volume (length density); Vv, volume of vessels per tumor volume (volumetric density); Sv, surface area of vessels per tumor volume (surface density). Mean ± 1SD, Mann-Whitney U test.
^aCHS 828 treatment for 10 days
^bChange compared to control
* p < 0.05 ** p < 0.01

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