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Table 2 Invasive pattern of orthotopic NB in SCID mice

From: Regression of orthotopic neuroblastoma in mice by targeting the endothelial and tumor cell compartments

  

Orthotopic mouse model

Clinical NB

Site

Control

at 10 days

CHS 828

at 10 days

CHS 828

at 30 days

[28]

Animals with metastases

100% (9/9)

46% (6/13)*

40% (4/10)*

 

Lung

11% (1/9)

0% (0/13)

0% (0/10)

34%

Liver

78% (7/9)

23% (3/13)*

0% (0/10)***

30%

Spleen

22% (2/9)

8% (1/13)

30% (3/10)

n.d.

Bone marrow

iliac crest

spinea

78% (7/9)

22% (2/9)

23% (3/13)*

8% (1/13)

10% (1/10)**

10% (1/10)

71%

Bone

n.d.

n.d.

n.d.

56%

Lymph nodes

n.d.

n.d.

n.d.

31%

Kidney invasion†

22% (2/9)

0% (0/13)

0% (0/10)

n.d.

  1. Metastatic spread in SCID mice carrying orthotopic NB xenotransplants treated either with CHS 828 (20 mg/kg/day) or vehicle compared to metastatic incidence of NB at INSS stages 4 and 4S in clinic [28]. Data shows microscopic metastases in the marrow of the iliac crest, and composite data of macro- and microscopic metastases to the organs.
  2. * < 0.05; ** < 0.01; *** < 0.001 (compared with controls); Fisher's exact test.
  3. aNB cells in the spine and kidney were regarded as continuous tumor growth.
  4. n.d., not determined; NB, neuroblastoma; INSS, International Neuroblastoma Staging System
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Journal of Translational Medicine

ISSN: 1479-5876

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