Regression of orthotopic neuroblastoma in mice by targeting the endothelial and tumor cell compartments

Table 1 CHS 828 toxicity profile

Triplicates of the NB cell lines IMR-32, SH-SY5Y, SK-N-SH cells (1 × 10⁵/ml), human foreskin fibroblasts CCD-1064SK (7.5 × 10⁴/ml) and endothelial cells htertBCE (2.5 × 10⁴/ml) were incubated with 16 different concentrations of CHS 828 for 24, 48 and 72 h (concentration range: 0.1 nM – 10 μM). Cell survival was measured by FMCA. Survival index was calculated as the percentage of viable cells at the actual concentration divided by percentage of viable cells in wells incubated without drug. Concentration intervals for IC₅₀.

ISSN: 1479-5876