Figure 5

Representative morphology and vessel profile in orthotopic NB xenografts. Vehicle-treated tumors (control) contained a larger number of small vessels (stained in brown) (A, C) compared to CHS 828 (20 mg/kg/day; p.o.) treated tumors (B, D-E) already 10 days after randomization. Vessels of control tumors had a thin endothelial cell lining (brown) (A, C). CHS 828 treated tumors revealed vessels only partly surrounded by endothelial cells (arrowheads) (B, D-E) or endothelial cells detaching from the basement membrane (arrows) (E). C and D are magnifications of A and B, respectively. Bandeiraea simplicifolia-1 (BS-1) lectin staining (brown); bar = 40 μm.