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Table 3 The expression of p53, p21/WAF1, and MDM2 in HCC tissues and clinical parameters

From: Correlation between expression of p53, p21/WAF1, and MDM2 proteins and their prognostic significance in primary hepatocellular carcinoma

  Cases(n) p53 positive p21/WAF1 positive MDM2 positive
   n (%) P value n (%) P value n (%) P value
Sex 181       
   Male 165 117(70.9) 0.857 53(32.1) 0.348 84(50.9) 0.174
   Female 16 11(68.8)   7(43.8)   11(68.8)  
Age 181       
   <45 y 75 55(73.3) 0.518 23(30.7) 0.553 38(50.7) 0.682
   ≥45 y 106 73(68.9)   37(34.9)   57(53.8)  
Tumor size 181       
   <5 cm 61 45(73.8) 0.523 21(34.4) 0.796 33(54.1) 0.758
   ≥5 cm 120 83(69.2)   39(32.5)   62(51.7)  
Tumor amount 181       
   1 145 100(69.0) 0.301 46(31.7) 0.417 74(51.0) 0.435
   ≥2 36 28(77.8)   14(38.9)   21(58.3)  
HbsAg 181       
   Positive 161 116(72.0) 0.267 53(32.9) 0.853 85(52.8) 0.815
   Negative 20 12(60.0)   7(35.0)   10(50.0)  
Histological gradeΔ 181       
   I+II 143 108(75.5) 0.007* 49(34.3) 0.627 75(52.4) 0.940
   III+IV 38 20(52.6)   11(28.9)   206(52.6)  
Serum AFP 181       
   <20 ng/ml 52 37(71.2) 0.935 22(42.3) 0.098 26(50.0) 0.673
   ≥20 ng/ml 129 91(70.5)   38(29.5)   69(53.5)  
  1. ΔHistological grade was with reference to the World Health Organization classification published in 2002.
  2. *Statistically significant (P < 0.05, 2-sided probability)