Correlation between expression of p53, p21/WAF1, and MDM2 proteins and their prognostic significance in primary hepatocellular carcinoma

Table 3 The expression of p53, p21/WAF1, and MDM2 in HCC tissues and clinical parameters

	Cases(n)	p53 positive		p21/WAF1 positive		MDM2 positive
		n (%)	P value	n (%)	P value	n (%)	P value
Sex	181
Male	165	117(70.9)	0.857	53(32.1)	0.348	84(50.9)	0.174
Female	16	11(68.8)		7(43.8)		11(68.8)
Age	181
<45 y	75	55(73.3)	0.518	23(30.7)	0.553	38(50.7)	0.682
≥45 y	106	73(68.9)		37(34.9)		57(53.8)
Tumor size	181
<5 cm	61	45(73.8)	0.523	21(34.4)	0.796	33(54.1)	0.758
≥5 cm	120	83(69.2)		39(32.5)		62(51.7)
Tumor amount	181
1	145	100(69.0)	0.301	46(31.7)	0.417	74(51.0)	0.435
≥2	36	28(77.8)		14(38.9)		21(58.3)
HbsAg	181
Positive	161	116(72.0)	0.267	53(32.9)	0.853	85(52.8)	0.815
Negative	20	12(60.0)		7(35.0)		10(50.0)
Histological grade^Δ	181
I+II	143	108(75.5)	0.007*	49(34.3)	0.627	75(52.4)	0.940
III+IV	38	20(52.6)		11(28.9)		206(52.6)
Serum AFP	181
<20 ng/ml	52	37(71.2)	0.935	22(42.3)	0.098	26(50.0)	0.673
≥20 ng/ml	129	91(70.5)		38(29.5)		69(53.5)

^ΔHistological grade was with reference to the World Health Organization classification published in 2002.
*Statistically significant (P < 0.05, 2-sided probability)

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