The Kaplan-Meier survival curves. The Kaplan-Meier survival of p53, p21/WAF1 and MDM2 in HCC. Positive or negative p53 expression did not correlate with the survival of patients (P = 0.275) (A). There was a significant difference in survival between patients with positive p21/WAF1 expression and negative p21/WAF1 expression (P = 0.026) (B) and between patients with negative MDM2 expression and positive MDM2 expression (P = 0.043) (C). There was a significant difference in survival between patients with p21+/MDM2- expression and p21-/MDM2+ expression (P = 0.012) (D).